SS-31 Peptide Article

SS-31 Peptide: Uses, Side Effects, Dosage, & Treatments

As people get older, they start suffering from various conditions that can negatively impact their lives. One reason is the importance of mitochondria to cellular metabolism. Mitochondrial dysfunction is responsible for a wide variety of conditions, so finding the right solution can be beneficial to a healthier life. This is where SS-31 comes into play. This is an excellent solution that can help you improve your health and the quality of your life.


SS-31 is a mitochondria-targeted peptide, which has been shown to be potentially highly effective in protecting and healing mitochondria damage. Most notably, it can potentially prevent issues like perioperative neurocognitive disorder or PND. PND is the term used to describe behavioral or cognitive changes that can potentially occur after surgery and anesthesia and is particularly common when it comes to older adults.

SS-peptides are referred to as ROS (reactive oxygen species) scavengers, which inhibit ROS long before they have the chance to damage the essential parts in the cell.

So how does SS-31 work? The issue with dysfunctional mitochondria is that it can cause oxidative stress, leading to various neurocognitive disorders. One study looked at LPS (lipopolysaccharide) induced inflammation and oxidative stress, leading to difficulties with learning and memory. LPS is the part of the cell wall that can activate the body’s immune response to infections. It can be responsible for cell death, inflammatory response, and oxidative stress. SS-31 is powerful in counteracting LPS.

SS-31 Uses

There are many benefits to using SS-31. In this section, you can get a closer look at some of the different ways that SS-31 can benefit you.

Improves Memory

LPS can create issues with your memory and learning. In a study with mice, mice were taught how to find their food in a maze. Some mice were exposed to LPS, and these mice ended up taking a long time to find their food. Once some mice received these peptides, they could go back to the same speed they had found their food before exposure to LPS.

Improves Mitochondria Function

SS-31 has been shown to be effective in protecting the brain from mitochondrial dysfunction. MMP (mitochondrial membrane potential) is used to indicate any mitochondrial activity. ATP (adenosine triphosphate) refers to the energy that the mitochondria create and is the fuel that the cells need to function. MMP allows not only cells to communicate with each other but also passes ATP back and forth. When there is low MMP, there can be wrong signals sent to the cells and a decrease in ATP function. SS-31 can help the body maintain proper MMP and ATP levels, which helps protect cell integrity.

Reduces Oxidative Stress and Inflammation

Oxidative stress is the result of an imbalance between ROS and cellular antioxidant defenses. If ROS is not appropriately kept in check, cell damage can take place. The brain uses a lot of energy, which is why it creates high levels of this ROS. Unfortunately, it also has a weak antioxidant defense, which is why it’s so susceptible to oxidative damage. This causes oxidative stress, which is linked to inflammation and can aggravate cell damage. SS-31 inhibits ROS, which will then suppress the inflammatory response in the body.

Prevents Cell Death (Cell Apoptosis)

Cells that produce too much ROS will inhibit electron transport. This will potentially lead to depolarizing membranes and cause cell death. SS-31 can remove ROS, which will prevent the activation of the cell death pathways. By doing this, you can be protected from mitochondrial dysfunction.

Therapeutic Benefits

Because SS-31 can improve and prevent mitochondrial dysfunction, this can help prevent a variety of different conditions, including:

  • Slow the aging process
  • Diabetes
  • Traumatic Brain Injury
  • Cardiovascular disease
  • Cancer
  • Muscular diseases

SS-31 Side Effects

SS-31 is generally considered to be a safe medication, which has minimal but mild side effects. Many of the adverse effects that people experience tend to be at the site of injection. However, there hasn’t been enough research on the long-term impact of using SS-31. This means usage beyond four weeks has not been as established.

Side effects of SS-31 includes:

  • Itching and mild redness at the site of injection
  • Headache
  • Dizziness

Your doctor will have more information about any potential side effects you may suffer from when you take this product. If you are experiencing symptoms that you find concerning, you should contact your doctor right away. They can let you know whether or not the symptoms are a side effect of SS-31 and what your next steps should be.

You should also check with your doctor before taking this medication if you are pregnant, planning to be pregnant, or breastfeeding to make sure that this product is safe for use.

SS-31 Dosage

The dosage for SS-31 could be upwards of 40mg per day. The exact dosage that is necessary can depend on what your specific needs are. The doctor will prescribe this medication and give you the proper dosage instructions for your condition. This medication is administered through injection, with 0.5-mL injections.

SS-31 Treatments

SS-31 is administered through injections. Your doctor can help you determine the proper dosage and give you instructions on how to properly administer this medication so that you can get the maximum benefit of this product.


Mitochondrial dysfunction can have a significant impact on your life. That’s why you must find a way to help improve your health. With SS-31, you can get the solution that you need to fight against aging and mitochondrial dysfunction that can hold you back from enjoying your life. As with any other medication, you should always check with your doctor to ensure that taking these products is safe for you and won’t interact with any other medications that you are taking. It’s always a good idea to work with your doctor as they can offer valuable advice to help you be as healthy as possible.

Are you ready to see how SS-31 can improve your overall health? Contact EVOLVE patient care to get started with treatment!

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