Tirzepatide vs Semaglutide: Which is More Effective for Weight Loss?

Weight loss medications are in demand, and on the rise in popularity. Tirzepatide and Semaglutide are weight loss drugs designed to suppress the body’s compensatory mechanisms during weight loss. Individuals with type 2 diabetes or those who suffer from weight gain can experience significant results in weight reduction over a period of time with these drugs. These medications work to reduce appetite and energy expenditure in order to combat the body’s natural response to weight loss. This blog post aims to compare and contrast both weight loss medications, and evaluate the overall effectiveness through previous research and studies.

Tirzepatide and Semaglutide pills next to a body tape

Tirzepatide and Semaglutide: The Way They Work

Both Tirzepatide and Semaglutide work differently in the body to promote weight loss. Tirzepatide, the active ingredient in Mounjaro, mimics the effect of both GLP-1 and GIP hormones, while Semaglutide, the active ingredient in Wegovy/Ozempic/Rybelsus, only mimics the effect of GLP-1 hormones. Since Tirzepatide mimics two hormones to assist weight loss, it’s also considered a “twincreatin” medicine. GLP-1 and GIP hormones send signals to the brain to stop food intake, and overall improve blood glucose levels. It’s crucial to choose the right medication based on individual needs because they’re regulated prescription drugs that can produce side effects if not taken properly. Therefore, people who are interested in taking this medication must consult a doctor to find the best fit for them before taking this medication.

Effectiveness of Tirzepatide and Semaglutide for Weight Loss

Studies show that Tirzepatide has proven to be the most effective weight loss medication over Semaglutide. However, the maximum dose of Tirzepatide was compared to a lower 1 mg dose of Semaglutide. Many claim that this was an unfair comparison and that the difference might have been negligible or lower had the full 2.4 mg dose of Semaglutide been administered. Also, this study focused on diabetes management rather than weight loss, and at the time of the study, Semaglutide’s highest approved dose for the treatment of diabetes was 1 mg. Now, the maximum dose for diabetes has been raised to 2 mg once a week (marketed as Ozempic), which is comparable to the 2.4 mg dose (marketed as Wegovy). The medication study of the brand name Mounjaro show weight loss results that were double or triple those of other weight loss drugs. These findings are comparable to those of bariatric surgery.

Here’s a short list of possible side effects of these prescription medications:

  • Nausea and vomiting
  • Severely depressed/suppressed appetite
  • Stomach pains, cramps, and diarrhea
  • Low blood glucose (especially for those with Type 2 diabetes)
  • Acute diseases in digestive tract organs and thyroid issues

Choosing the Right Weight Loss Medication

Factors to consider when choosing between Tirzepatide and Semaglutide include knowing the risk of taking either of these medications, speaking with a healthcare professional to determine which drug and dosage works best for you, the cost of treatment, and identifying any symptoms while taking the medication. Both Tirzepatide and Semaglutide have proven to induce weight loss, but there are some things to consider. Semaglutide is more expensive than Tirzepatide, but Semaglutide has been on the market longer and thus approved safe to treat diabetes and obesity first. Weight management is a serious health concern, and it’s vital to consult with a certified doctor before taking either of these medications. Consider booking an appointment with a healthcare professional at Evolve Telemedicine today to see which treatment option makes sense for you.

Other Weight Loss Pills

Other approved medications for long-term use in weight management include Naltrexone-bupropion, Orlistat, Liraglutide, and Phentermine-topiramate among others. Naltrexone-bupropion controls appetite by acting on the brain’s reward system to curb food cravings. Whereas Orlistat works by decreasing the absorption of fat from the intestines. Liraglutide is a weight loss medicine that works by delaying gastric emptying and increasing feelings of satiety after meals. Phentermine-topiramate regulates appetite to reduce overall caloric intake.

Here is the list of possible side effects and safety concerns for each alternative weight loss medication:


  • Nausea
  • Constipation
  • Headache
  • High blood pressure
  • Possible suicidal thoughts or actions


  • Gastrointestinal symptoms like flatulence and loose stools
  • In rare cases, some people may develop a severe liver injury


  • Nausea and vomiting
  • Can increase the risk of thyroid tumors


  • Insomnia
  • Nervousness
  • Constipation
  • Increased heart rate 
  • High blood pressure
  • Risks include the potential for abuse (phentermine acts like an amphetamine) and birth defects due to topiramate

Start Losing Weight Today

When it comes to weight loss, the delicate subject can be a difficult feat- but it doesn’t have to be!

While both Tirzepatide and Semaglutide work to decrease weight, Tirzepatide has proven to show a greater percentage of weight loss through studies. It’s important to note that side effects are apparent in either medication, and you may be vulnerable to other risks as well. Researching and scheduling an appointment with a healthcare professional is key to figuring out which weight loss medication is most appropriate for your body and situation. For more information visit the Evolve Telemedicine website or call (800) 407-4117 to schedule a consultation.

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